Aminoacyl Sulfamide Compounds that Inhibit Cancerous Cell Growth and Virus Spreading

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Xin Qi
Xiao Liang
Ravil Khaybullin
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Anita Rao
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Potent Anti-Cancer and Anti-Viral Compounds Inhibit Cancer Cell Proliferation and Replication of HIV

This series of chemical compounds reduce the spread of cancerous cells and viruses, by suppressing their ability to synthesize proteins and replicate viruses. Transfer RNA (tRNA) and messenger RNA (mRNA) are important for the replication and spread of cancerous cells. Aminoacyl sulfamides, which are stable compounds structurally mimicking cognate intermediates, can be high-affinity inhibitors of aminoacyl tRNA synthetase activity. By inhibiting aminoacyl tRNA synthetase activity, the aminoacyl sulfamides have anticancer or antiviral properties. University of Florida researchers have developed variants of aminoacyl sulfamides with efficient synthesis procedures. In early tests, they are effective at low concentrations in reducing the spread of cancer cell lines, such as breast, lung, pancreas, prostate, colon and leukemia cells. The compounds also effectively inhibit HIV infected cell replication.

Application

Anticancer or antiviral drug development from aminoacyl sulfamide compounds

Advantages

  • Suppress cancerous cell proliferation and viral replication, reducing the spread of the cancer and virus
  • Achieve a high rate of inhibition at low concentrations, improving overall effectiveness

Technology

These aminoacyl sulfamide compounds use their potent ability to impede the function of tRNA synthetase therapy, preventing viruses or cancer cells from reproducing or replicating inside a host. The synthesized aminoacyl sulfamides can bear lactam structure, such as pyroglutamyl fragment (pGlu-SA). Aminoacyl sulfamides are structural mimics of aminoacyl adenylates (aaAMPs), acting as aminoacyl tRNA synthetase inhibitors. By inhibiting the function of tRNA synthetase, the aminoacyl sulfamide compounds suppress not only cell growth and viral replication but also cancer cell metastasis. Researchers have evaluated the compounds on human acute lymphoblastic leukemia, human acute promyelocytic leukemia, breast cancer, lung cancer, colon cancer, cervical cancer, and prostate cancer.