Monoclonal Antibody Against Immune-regulatory slpA

Technology #15122

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Researchers
Mansour Mohamadzadeh
Bikash Sahay
Managed By
John Byatt
Assistant Director 352-392-8929

Scientists at the University of Florida have developed a wide variety of monoclonal and polyclonal antibodies, cell lines, vectors and biological materials that can be used in other research projects. Anyone interested in accessing these materials via a license from the University of Florida should contact our office to make arrangements. Lactobacillus acidophilus NCFM is one of the most widely recognized and commercially distributed probiotic cultures. It has been recently discovered that the major S layer protein, SlpA, of L. acidophilus NCFM is functionally involved in the modulation of dendritic cell and T cell function (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592362/). High affinity monoclonal antibodies that recognize slpA have been developed that can be used to study this new and important immune-regulatory molecule. The researchers have used these antibodies with a number of techniques including ELISA, Western blotting and flow-cytometry.