Device for "Phantom-less" fMRI Standardization

Technology #12038

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Keith D. White
Managed By
Zahara M. Jaffer
Assistant Director 352-392-8929
Patent Protection
PCT Patent Application WO 2007/124320
US Patent 7,863,896

Improves Medical Test Reliability by Enhancing Specificity and Sensitivity

This device improves functional magnetic resonance imaging (fMRI) test reliability. fMRI interpretation is challenging due to imperfect repeatability, even when using calibrated equipment and consistent test procedures. The living human body introduces multiple sources of variance into the measurements. Our researcher has developed a process to standardize fMRI across platforms, across scans, and across people to improve consistency among fMRI tests.


Reliable fMRI testing by technicians and manufacturers


  • Increased reliability leading to a significant market advantage in a $3.5 billion industry
  • Provides process to standardize fMRI across, platforms, scans, and people, offering opportunity for tremendous market penetration


This device uses electronically controlled field inhomogeneity to simulate endogenous blood oxygenation responses. Unlike the body’s endogenous responses, the simulations are computer controlled, highly reproducible, and can be calibrated in physical units (e.g., microTesla). During a scan the person embodies both simulated and endogenous signals; no phantom is required. The simulated and endogenous signals can both be extracted from the acquired images and compared. The specific externally-controlled simulated signal statistically equivalent to the endogenous signal becomes the test result, a calibrated measure that is platform-, scan-, and person-independent.