Monoclonal Antibody Against HKE2: A Novel Tumor AntigenĀ 

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Researchers
David A. Ostrov
Managed By
April Kilburn
Assistant Director 352-392-8929

Targeting Protein Involved in Stabilizing Proteins Before Folding

Scientists at the University of Florida have developed a wide variety of monoclonal and polyclonal antibodies, cell lines, vectors and biological materials that can be used in other research projects. Anyone interested in accessing these materials via a license from the University of Florida should contact our office to make arrangements. Prefoldin 6 is a subunit of a hexameric molecular chaperone complex, named prefoldin. This chaperon complex is built from two related classes of subunits and is present in all eukaryotes and archaea. The prefoldin complex interacts with nascent polypeptide chains to stabilize non-native proteins (such as actins and tubulins) for subsequent folding in the central cavity of a chaperonin. The prefoldin 6 gene is located in the human MHC class II region and is also known as HKE2. Journal article: http://onlinelibrary.wiley.com/doi/10.1111/j.1399-0039.2006.00730.x/abstract;jsessionid=056A60F7E4724A40CA504C889EEF0225.d04t01