Targeting Aberrant Forms of a Protein Associated with Genetic Disease
Scientists at the University of Florida have developed a wide variety of monoclonal and polyclonal antibodies, cell lines, vectors and biological materials that can be used in other research projects. Anyone interested in accessing these materials via a license from the University of Florida should contact our office to make arrangements. Neurofibromin is a GTPase-activating oncoprotein modulating the ras pathway. Neurofibromin is known to have several isoforms resulting from mRNA splice variants. Also, the genetics of NF1 disease may result in aberrant or truncated forms of neurofibromin with altered function. The monoclonal antibody was raised against the neurofibromatosis type 1 (NF1) gene product, neurofibromin using a unique peptide corresponding to peptides 27-41 of the highly conserved N-terminal sequence of mammalian neurofibromin. The antibody binds to human and rodent neurofibromin and is particularly effective in immunohistochemical labeling.
Journal article: http://www.jneurosci.org/content/25/23/5584.long (Journal of Neuroscience subscription required)