Human Health Care » Drug Delivery

Found 25 technologies within Drug Delivery RSS ATOM

Drug Delivery Vehicle for Use in the Treatment of Central and Peripheral Nervous System Disorders

13980 – These liposomal nanoparticles deliver therapeutic, labeling, and imaging agents to disease sites within the central or the peripheral nervous system. Neurological disorders are diseases of the central and peripheral nervous system. Neurological disorders are an important cause of mortality and cause approximately 12 percent of deaths worldwide. Current treatments cannot effectively... Read More

B Cell Depletion Antibody for Enhanced AAV-Mediated Gene Transfer

15136 – This B cell depletion antibody increases both safety and efficiency of gene therapy by inhibiting the immune system responses to AAV gene transfer over multiple treatments. AAV gene transfer has proven to be useful in treating a number of diseases, including congestive heart failure, Parkinson’s disease, and hemophilia. Unfortunately, traditional methods of AAV gene transfer can trigger... Read More

AAV Modification for Improved Gene Therapy of Eye and Brain Tissue

16103 – This adeno-associated virus (AAV) vector contains mutations in AAV2 capsid amino acids that are defective for heparin binding and have been found to increase transduction efficiency and biodistribution of gene therapy in the eyes and brain. Gene therapy has become increasingly popular among researchers in the medical field for treatment of diseases and disorders in the eyes and brain... Read More

Polymeric Microparticle Blends for Enhanced Cytosolic Drug Delivery

15974 – Drug delivery systems utilizing microparticle blends that incorporate poly(propylacrylic acid) into poly(lactide-co-glycolide) improve intracellular cytosolic delivery of bioactive molecules. The therapeutic potential of bioactive molecules delivered by microparticles is reduced considerably when the microparticles accumulate in cellular lysosomal compartments without being released... Read More

Magnetically-Triggered Drug Delivery Vehicles for Controlled, Targeted Therapy

14866 – This magnetically-triggered drug delivery platform can deliver a wide array of nano-medicines to targeted cells in the body. Nanotechnology is a growing science that is useful in targeting and treating cancerous cells and other harmful agents. The global market for nanoparticles in life sciences is estimated at over $30 billion. While a variety of available nano-medicines allow for... Read More

Iron Chelator Prodrug that Prevents Skin Damage from UV Radiation

15352 – When applied topically, this oxidative stress-activatable double prodrug chelates iron in the body, helping to prevent skin damage caused by ultraviolet (UV) radiation from the sun. Over time, UV radiation can stress the skin by triggering the release of free iron, which subsequently leads to the production of reactive oxygen species (ROS). At high levels, ROS can damage lipids,... Read More

Computer-Guided Orthodontic Tools for Optimal and Efficient Placement of Braces

15180 – This computer-guided bracket positioning device and indexing tool employs tracking sensors for more precise, efficient, and effective orthodontic bracket placement. In the United States alone, more than 4 million people wear braces. These patients invest thousands of dollars into orthodontic procedures to align their smiles and prevent complications due to crooked teeth or misaligned... Read More

Electroactive Biodegradable Polymers for Targeted Drug Therapy

15068 – Biodegradable supramolecular polymers that receive and transmit electrochemical information may be employed for efficient and effective medicinal treatment. Targeted drug delivery (occasionally employing stimuli-responsive materials) has been effectively utilized since the early 2000s for such life-threatening illnesses as cancer, Alzheimer’s disease, epilepsy, and cardiovascular... Read More

Electroactive Biomaterials that Can Be Used to Repair Peripheral Nerve Defects

15355 – This biomaterial composed of electroactive polymers utilizes electrical stimulation of cells to promote nerve regeneration within the peripheral nervous system. The field of regenerative medicine continually attracts increasing attention from investors and industries, surpassing $1 billion in annual revenue in 2013. Autografts, which take a functioning section of a nerve from elsewhere... Read More

Contraction-Sensitive Medication Release System to Reduce Labor Pain

13662 – This contraction-sensitive medication release system dramatically reduces labor pain by administering analgesic relief to match timing and intensity of contractions in real time. Labor can be an extremely painful experience, and many women opt for medications or methods to numb the nerves sensing pain during childbirth. Although a variety of options exist for pain relief during labor, most... Read More

Nanozymes for Treating Viral Infections and Cancer

14709 – These nanozymes can be loaded with drugs to target and treat cancers and viral infections. The term nanozyme is a combination of the words nanoparticle and enzyme. Nanoparticles are simply the smallest units of matter that retain the ability to function as a single entity. Enzymes are proteins that increase the rates of chemical reactions, thereby allowing cells to quickly build or... Read More

Non-Collapsible Device for Safer IV Fluid Administration during Pressurized Fluid Delivery

15243 – This intravenous fluid safety device, for use during pressurized delivery of fluids, can work with existing medical pressure infusion cuffs to contain air inside intravenous (IV) bags, preventing the administration of an air bolus to a patient’s bloodstream. An IV line connected to a bag of fluid infuses fluid directly into a patient’s vein via a central venous line catheter. To... Read More

Receptor-Ligand Combination for Specific Drug Delivery to the Brain

15383 – This engineered receptor-ligand combination targets and crosses the brain barriers of mammals to deliver drugs and therapeutics to the brain. About 12 percent of all deaths worldwide are caused by neurological disorders such as Alzheimer’s, Parkinson’s and epilepsy. Neurological disorders represent a large area of unmet medical need due to the limited efficiency of treatments available.... Read More

Mutated AAV2-Based Vector for Efficient Transduction of Photoreceptors and Retinal Pigment Cells

15100 – This AAV2-based capsid variant achieves higher transduction of photoreceptors and retinal pigment cells following subretinal injection. This AAV2-based vector could therefore improve the efficiency of retinal gene therapy by increasing transduction of retinal cells after injection. AAV vector-based therapy has proven to be useful in treating a number of diseases, including congestive... Read More

Cell-based Arrays for Screening Combination Drug Efficacy for Personalized Cancer Therapy

14780 – These cell-based arrays use a small sampling of cells to help isolate and identify a patient’s sensitivity to chemotherapeutic drugs in vitro, potentially personalizing treatment of cancer. The cancer stem cell hypothesis postulates that a minute fraction of cells within a tumor, termed cancer stem cells, possess the tumor-initiating capacity that propels tumor growth. Targeting... Read More

Vitamin C Prodrug that Delivers Antioxidant Benefits to Rejuvenate Skin

14636 – This vitamin C prodrug, when added to topical creams and anti-aging cosmetics, delivers antioxidant benefits for improving skin’s appearance. Among humans and other animals, vitamin C is essential for many important biological/biochemical functions. It is also added to foods and cosmetics to prevent oxidation of organic components. This vitamin is believed to improve skin’s appearance... Read More

Gene Therapy to Prevent the Progression of Multiple Sclerosis (MS)

15158 – This gene therapy treatment re-establishes immune tolerance in order to halt the progression of multiple sclerosis, a debilitating disease that affects more than 2.3 million people worldwide. Adeno-associated virus gene therapy (AAV therapy) has been proven as a powerful tool for the treatment of a broad spectrum of diseases. Researchers at the University of Florida have developed the... Read More

Viral Vector to Treat Age-Related Macular Degeneration and Other Eye Diseases

14807 – This viral vector treats eye diseases through a safer, less invasive injection and could restore useful vision to individuals with a type of age-related macular degeneration that affects more than 2 million people. “Dry” age-related macular degeneration occurs when photoreceptors in the eye are damaged or begin to atrophy, resulting in vision loss. There are no available treatments... Read More

Helix Antenna that Powers and Communicates with Implanted Medical Devices

14531 – This omnidirectional, wireless helix antenna provides power to implanted medical devices and capsule endoscopes, while allowing these devices to better relay health information for easier diagnosis and treatment. Every year in the U.S., more than $85 billion is spent on implanted medical devices, including $5.5 billion and $4.5 billion on defibrillators and pacemakers, respectively. These... Read More

Smart Mouth Guard for Identifying and Managing Bruxism, Grinding of Teeth

14329 – This smart mouth guard helps diagnose, quantify and manage bruxism, the excessive grinding of teeth and/or clenching of the jaw. Because bruxism involves damaging movements of the mandible that are outside normal function, it is considered an oral parafunctional activity. It can occur while awake or asleep and affects between five and 20 percent of Americans, 80 percent of whom are... Read More

Nanoparticle-Coupled Regulatory T-Cells for the Treatment of Type 1 Diabetes

13837 – This drug-delivery system, including nanoparticle-coupled regulatory T-cells, prevents and treats Type 1 diabetes and other autoimmune diseases, such as rheumatoid arthritis, lupus and multiple sclerosis. The system also has potential to deliver treatments for graft- versus-host disease and transplant rejection. Typically resulting from a combination of genetic and environmental factors,... Read More

Drug-Delivery System for Prevention and Treatment of Autoimmune Diseases Including Type 1 Diabetes

13603 – This drug-delivery system prevents and treats Type 1 diabetes and other autoimmune diseases, such as rheumatoid arthritis, lupus and multiple sclerosis. Autoimmune diseases cause the body to attack its own cells, tissues and organs. In the United States 15 million to 24 million people, about 8 percent of the population, have autoimmune diseases. These diseases typically result from a... Read More

Nanozymes for Treating Viral Infections and Cancer

13338 – The University of Florida is seeking companies interested in commercializing nanozyme technology for treating cancers and viral infections. The term nanozyme is a combination of the words nanoparticle and enzyme. Nanoparticles are simply the smallest units of matter that retain the ability to function as a single entity. Enzymes are proteins that increase the rates of chemical reactions,... Read More

Materials For More Safely And Efficiently Generating Reprogrammed Cells For Cell Therapy

13320 – The University of Florida is seeking companies interested in commercializing new nuclear-protein-delivery materials for more efficient cellular reprogramming that, because it doesn’t require genetic modification, is more acceptable to regulatory agencies. These reprogrammed cells can be used in regenerative therapy for genetic, metabolic and degenerative disorders. It has been known for... Read More

Innovative Labor Pain Management System

12043 – The University of Florida is seeking companies interested in commercializing a groundbreaking method of treating labor pain with a contraction- sensitive medication release system. Labor can be an extremely painful experience, and many women opt for medications or methods to numb the nerves sensing pain during childbirth. Although a variety of options exist for pain relief during labor,... Read More