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17551 – Allows Externally-controlled Delivery of Large Macromolecules for Dynamic, Spatial and Temporal Release Of Biologics This drug delivery system addresses the previously unmet need of a controlled drug-release platform for large biomolecules, such as growth factors and proteins. Controlled drug-release technology is one of the most rapidly growing technologies in human healthcare with market... Read More
16485 – These biodegradable drug nanocarriers adhere to the extracellular matrix of cartilage, improving drug efficacy in joints during surgery or arthroscopy for those with osteoarthritis. Osteoarthritis (OA) is a disease characterized by the degeneration of cartilage in any joints in the body. This disease affects approximately 27 million Americans and has no cure. Available intra-articular... Read More
13980 – These liposomal nanoparticles deliver therapeutic, labeling, and imaging agents to disease sites within the central or the peripheral nervous system. Neurological disorders are diseases of the central and peripheral nervous system. Neurological disorders are an important cause of mortality and cause approximately 12 percent of deaths worldwide. Current treatments cannot effectively... Read More
16103 – This adeno-associated virus (AAV) vector contains mutations in AAV2 capsid amino acids that are defective for heparin binding and have been found to increase transduction efficiency and biodistribution of gene therapy in the eyes and brain. Gene therapy has become increasingly popular among researchers in the medical field for treatment of diseases and disorders in the eyes and brain... Read More
15974 – Drug delivery systems utilizing microparticle blends that incorporate poly(propylacrylic acid) into poly(lactide-co-glycolide) improve intracellular cytosolic delivery of bioactive molecules. The therapeutic potential of bioactive molecules delivered by microparticles is reduced considerably when the microparticles accumulate in cellular lysosomal compartments without being released... Read More
14866 – This magnetically-triggered drug delivery platform can deliver a wide array of nano-medicines to targeted cells in the body. Nanotechnology is a growing science that is useful in targeting and treating cancerous cells and other harmful agents. The global market for nanoparticles in life sciences is estimated at over $30 billion. While a variety of available nano-medicines allow for... Read More
15180 – This computer-guided bracket positioning device and indexing tool employs tracking sensors for more precise, efficient, and effective orthodontic bracket placement. In the United States alone, more than 4 million people wear braces. These patients invest thousands of dollars into orthodontic procedures to align their smiles and prevent complications due to crooked teeth or misaligned... Read More
15068 – Biodegradable supramolecular polymers that receive and transmit electrochemical information may be employed for efficient and effective medicinal treatment. Targeted drug delivery (occasionally employing stimuli-responsive materials) has been effectively utilized since the early 2000s for such life-threatening illnesses as cancer, Alzheimer’s disease, epilepsy, and cardiovascular... Read More
15355 – This biomaterial composed of electroactive polymers utilizes electrical stimulation of cells to promote nerve regeneration within the peripheral nervous system. The field of regenerative medicine continually attracts increasing attention from investors and industries, surpassing $1 billion in annual revenue in 2013. Autografts, which take a functioning section of a nerve from elsewhere... Read More
13662 – This contraction-sensitive medication release system dramatically reduces labor pain by administering analgesic relief to match timing and intensity of contractions in real time. Labor can be an extremely painful experience, and many women opt for medications or methods to numb the nerves sensing pain during childbirth. Although a variety of options exist for pain relief during labor, most... Read More
15243 – This intravenous fluid safety device, for use during pressurized delivery of fluids, can work with existing medical pressure infusion cuffs to contain air inside intravenous (IV) bags, preventing the administration of an air bolus to a patient’s bloodstream. An IV line connected to a bag of fluid infuses fluid directly into a patient’s vein via a central venous line catheter. To... Read More
15383 – This engineered receptor-ligand combination targets and crosses the brain barriers of mammals to deliver drugs and therapeutics to the brain. About 12 percent of all deaths worldwide are caused by neurological disorders such as Alzheimer’s, Parkinson’s and epilepsy. Neurological disorders represent a large area of unmet medical need due to the limited efficiency of treatments available.... Read More
15100 – This AAV2-based capsid variant achieves higher transduction of photoreceptors and retinal pigment cells following subretinal injection. This AAV2-based vector could therefore improve the efficiency of retinal gene therapy by increasing transduction of retinal cells after injection. AAV vector-based therapy has proven to be useful in treating a number of diseases, including congestive... Read More
14780 – These cell-based arrays use a small sampling of cells to help isolate and identify a patient’s sensitivity to chemotherapeutic drugs in vitro, potentially personalizing treatment of cancer. The cancer stem cell hypothesis postulates that a minute fraction of cells within a tumor, termed cancer stem cells, possess the tumor-initiating capacity that propels tumor growth. Targeting... Read More
15158 – This gene therapy treatment re-establishes immune tolerance in order to halt the progression of multiple sclerosis, a debilitating disease that affects more than 2.3 million people worldwide. Adeno-associated virus gene therapy (AAV therapy) has been proven as a powerful tool for the treatment of a broad spectrum of diseases. Researchers at the University of Florida have developed the... Read More
14531 – This omnidirectional, wireless helix antenna provides power to implanted medical devices and capsule endoscopes, while allowing these devices to better relay health information for easier diagnosis and treatment. Every year in the U.S., more than $85 billion is spent on implanted medical devices, including $5.5 billion and $4.5 billion on defibrillators and pacemakers, respectively. These... Read More
13338 – These nanozymes reach targeted sites of infection or abnormal cell growth to deliver drugs that treat cancers and viral infections. According to the American Cancer Society, half of men and a third of women develop cancer during their lives. Similarly, viruses such as influenza, hepatitis B, and hepatitis C are widespread and life-threatening. These create a strong demand for effective... Read More
13320 – The University of Florida is seeking companies interested in commercializing new nuclear-protein-delivery materials for more efficient cellular reprogramming that, because it doesn’t require genetic modification, is more acceptable to regulatory agencies. These reprogrammed cells can be used in regenerative therapy for genetic, metabolic and degenerative disorders. It has been known for... Read More
12043 – This groundbreaking labor pain management system releases analgesic medication based on contraction timing, relieving pain without severe neuromuscular blocking. Childbirth can be an extremely painful experience for women, many of whom tend to opt for medications that numb pain-sensitive nerves during labor. Although a variety of options exist for pain relief during labor, most women... Read More
